The Role of Photodynamic Therapy for Hilar Cholangiocarcinoma
نویسندگان
چکیده
منابع مشابه
The Role of Photodynamic Therapy for Hilar Cholangiocarcinoma
The prognosis for hilar cholangiocarcinoma is limited by tumor spread along the biliary tree leading to refractory obstructive cholestasis, cholangitis, and liver failure. Palliation with biliary endoprostheses results in median survival times of 4-6 months for advanced bile duct cancer. Photodynamic therapy (PDT) is a local photochemical tumor treatment consisting of a photosensitizing agent c...
متن کاملPhotodynamic Therapy Plus Chemotherapy Compared with Photodynamic Therapy Alone in Hilar Nonresectable Cholangiocarcinoma
BACKGROUND/AIMS Standard treatments are not available for hilar nonresectable cholangiocarcinoma (NCC). It is unknown whether combination therapy of photodynamic therapy (PDT) plus systemic chemotherapy is superior to PDT alone. METHODS We retrospectively reviewed 68 patients with hilar NCC treated with either PDT plus chemotherapy (PTD-C) or PDT monotherapy (PDT-M). The primary endpoint was ...
متن کاملPhotodynamic Therapy for Perihilar Cholangiocarcinoma
Haroon Shahid, MD, Fellow, Division of Gastroenterology and Hepatology David Loren, MD FASGE, Associate Director, Gastrointestinal Endoscopy, Associate Professor of Medicine Sidney Kimmel College of Medicine Thomas Jefferson University Cholangiocarcinoma of the biliary hilum is an uncommon disease but increasing in incidence. Patients affected by this frequently fatal disease often succumb to c...
متن کاملNon-surgical Therapy for Unresectable Hilar Cholangiocarcinoma
Hilar cholangiocarcinoma (HCCA) is characterised by late clinical symptoms. As a consequence, most patients will not undergo surgery, and palliation is the main goal of therapy. For the few patients that undergo potentially curative surgery, the need for preoperative biliary drainage (PBD) continues to be debated and remains controversial, as there are many reports with conflicting results. For...
متن کاملLong-Term Outcome of Photodynamic Therapy with Systemic Chemotherapy Compared to Photodynamic Therapy Alone in Patients with Advanced Hilar Cholangiocarcinoma
BACKGROUND/AIMS Patients with cholangiocarcinoma usually present at an advanced stage, and more than 50% of cases are not resectable at the time of diagnosis. Recently, photodynamic therapy (PDT) has been proposed as a palliative and neoadjuvant modality. We evaluated whether combination of PDT and chemotherapy is more effective than PDT alone. METHODS In total, 161 patients with cholangiocar...
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ژورنال
عنوان ژورنال: The Korean Journal of Internal Medicine
سال: 2010
ISSN: 1226-3303
DOI: 10.3904/kjim.2010.25.4.345